Files

645957.pdf (2.27 MB)

Document type

Article

Version

Published version

Publication date

2015-01-30

Publication license

cc-by (c) Navarro Ponz, Alfons et al., 2014
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/111722

A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma

Journal Title

Authors

Director/Tutor

Additional contribution

Journal ISSN

Volume Title

Abstract

We have examined serum microRNA expression in multiple myeloma (MM) patients at diagnosis and at complete response (CR) after autologous stem-cell transplantation (ASCT), in patients with stable monoclonal gammopathy of undetermined significance, and in healthy controls. MicroRNAs were first profiled using TaqMan Human MicroRNA Arrays. Differentially expressed microRNAs were then validated by individual TaqMan MicroRNA assays and correlated with CR and progression-free survival (PFS) after ASCT. Supervised analysis identified a differentially expressed 14-microRNA signature. The differential expression of miR-16 (P = 0.028), miR-17 (P = 0.016), miR-19b (P = 0.009), miR-20a (P = 0.017) and miR-660 (P = 0.048) at diagnosis and CR was then confirmed by individual assays. In addition, high levels of miR-25 were related to the presence of oligoclonal bands (P = 0.002). Longer PFS after ASCT was observed in patients with high levels of miR-19b (6 vs. 1.8 years; P < 0.001) or miR-331 (8.6 vs. 2.9 years; P = 0.001). Low expression of both miR-19b and miR-331 in combination was a marker of shorter PFS (HR 5.3; P = 0.033). We have identified a serum microRNA signature with potential as a diagnostic and prognostic tool in MM.

Related resource

https://doi.org/10.18632/oncotarget.2761

Subject

Micro RNAs, Sèrum, Mielomatosi, Trasplantament d'òrgans

Subject (English)

MicroRNAs, Serum, Myeloproliferative disorders, Transplantation of organs

Citation

Collections

Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

NAVARRO PONZ, Alfons, et al. A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma. Oncotarget. 2014. Vol. 6, num. 3, pags. 1874-1883. ISSN 1949-2553. [consulted: 7 of October of 2026]. Available at: https://hdl.handle.net/2445/111722

Export metadata

JSON - METS

Share record