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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/211640
Hypoconnectivity networks in schizophrenia patients: A voxel-wise meta-analysis of Rs-fMRI
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Background: In recent years several meta-analyses regarding resting-state functional connectivity in patients with schizophrenia have been published. The authors have used different data analysis techniques: regional homogeneity, seed-based data analysis, independent component analysis, and amplitude of low frequencies. Hence, we aim to perform a meta-analysis to identify connectivity networks with different activation patterns between people diagnosed with schizophrenia and healthy controls using voxel-wise analysis. Method: We collected primary studies exploring whole brain connectivity by functional magnetic resonance imaging at rest in patients with schizophrenia compared with healthy controls. We identified 25 studies included high-quality studies that included 1285 patients with schizophrenia and 1279 healthy controls. Results: The results indicate hypoactivation in the right precentral gyrus and the left superior temporal gyrus of patients with schizophrenia compared with healthy controls. Conclusions: These regions have been linked with some clinical symptoms usually present in Plea with schizophrenia, such as auditory verbal hallucinations, formal thought disorder, and the comprehension and production of gestures.
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RUIZ-TORRAS, Silvia, et al. Hypoconnectivity networks in schizophrenia patients: A voxel-wise meta-analysis of Rs-fMRI. International Journal of Clinical And Health Psychology. 2023. Vol. 23, num. 4, pags. 100395. ISSN 1697-2600. [consulted: 13 of October of 2026]. Available at: https://hdl.handle.net/2445/211640