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2008-02-01
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/25183

Activation of Srk1 by the Mitogen-activated Protein Kinase Sty1/Spc1 Precedes Its Dissociation from the Kinase and Signals Its Degradation

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Recurs relacionat

http://dx.doi.org/10.1091/mbc.E07-07-0639

Resum

Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. The Schizosaccharomyces pombe SAPK Sty1/Spc1 orchestrates general changes in gene expression in response to diverse forms of cytotoxic stress. Here we show that Sty1/Spc1 is bound to its target, the Srk1 kinase, when the signaling pathway is inactive. In response to stress, Sty1/Spc1 phosphorylates Srk1 at threonine 463 of the regulatory domain, inducing both activation of Srk1 kinase, which negatively regulates cell cycle progression by inhibiting Cdc25, and dissociation of Srk1 from the SAPK, which leads to Srk1 degradation by the proteasome.

Matèries

Proteïnes quinases, Llevats, Cicle cel·lular

Matèries (anglès)

Protein kinases, Yeast, Cell cycle

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Articles publicats en revistes (Biomedicina)

Citació

LÓPEZ AVILÉS, Sandra, et al. Activation of Srk1 by the Mitogen-activated Protein Kinase Sty1/Spc1 Precedes Its Dissociation from the Kinase and Signals Its Degradation. Molecular Biology of the Cell. 2008. Vol. 19, núm. 4, pàgs. 1670-1679. ISSN 1059-1524. [consulta: 8 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/25183

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