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TFG_QU_Guo Luo Lili.pdf (1.45 MB)

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Treball de fi de grau

Data de publicació

2015-06

Llicència de publicació

cc-by-nc-nd (c) Guo Luo, 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/66360

Determination of non-steroidal anti-inflammatory drugs in milk by liquid chromatography-tandem mass spectrometry (LC-MS/MS)

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Resum

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in human and veterinary medicine because of their main properties: anti-inflammatory, analgesic and antipyretic. The use of these drugs has increased significantly over the world in the last decades. The widespread use of NSAIDs can cause serious side effects such as gastric and intestinal disturbances. The control of the presence of residues of NSAIDs in food of animal origin is mandatory following Europe legislation; for this reason analytical methods for milk and meat analysis have to be set up. In this work, a method based on the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) approach was developed for the determination of NSAIDs in milk samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionization (ESI) using the Multiple Reaction Monitoring (MRM) mode. A new sample preparation method was developed, using 5% acetic acid in acetonitrile as extraction system and with a clean-up step by dispersive solid phase extraction (d-SPE) using sorbent C18. Mass spectrometric parameters and chromatographic separation were optimized. Two MRM transitions were monitored for each analyte in positive or negative electrospray mode.

Descripció

Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2015, Tutors: Antoni Rúbies Prat i Mercè Granados Juan

Matèries

Cromatografia de líquids, Espectrometria de masses, Antiinflamatoris no esteroïdals, Treballs de fi de grau

Matèries (anglès)

Liquid chromatography, Mass spectrometry, Nonsteroidal anti-inflammatory agents, Bachelor's theses

Citació

Col·leccions

Treballs Finals de Grau (TFG) - Química

Citació

GUO LUO, Lili. Determination of non-steroidal anti-inflammatory drugs in milk by liquid chromatography-tandem mass spectrometry (LC-MS/MS). [consulta: 24 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/66360]

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