Miniatura

Fitxers

880465.pdf (6.36 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2024-06-11

Llicència de publicació

cc-by (c) Solana-Balaguer, J. et al., 2024
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/221899

Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1186/s12964-024-01693-9

Resum

Huntington’s disease (HD) is a neurological disorder caused by a CAG expansion in the Huntingtin gene (HTT). HD pathology mostly affects striatal medium-sized spiny neurons and results in an altered cortico-striatal function. Recent studies report that motor skill learning, and cortico-striatal stimulation attenuate the neuropathology in HD, resulting in an amelioration of some motor and cognitive functions. During physical training, extracellular vesicles (EVs) are released in many tissues, including the brain, as a potential means for inter-tissue communication. To investigate how motor skill learning, involving acute physical training, modulates EVs crosstalk between cells in the striatum, we trained wild-type (WT) and R6/1 mice, the latter with motor and cognitive deficits, on the accelerating rotarod test, and we isolated their striatal EVs. EVs from R6/1 mice presented alterations in the small exosome population when compared to WT. Proteomic analyses revealed that striatal R6/1 EVs recapitulated signaling and energy deficiencies present in HD. Motor skill learning in R6/1 mice restored the amount of EVs and their protein content in comparison to naïve R6/1 mice. Furthermore, motor skill learning modulated crucial pathways in metabolism and neurodegeneration. All these data provide new insights into the pathogenesis of HD and put striatal EVs in the spotlight to understand the signaling and metabolic alterations in neurodegenerative diseases. Moreover, our results suggest that motor learning is a crucial modulator of cell-to-cell communication in the striatum.

Matèries

Escorça cerebral, Malalties neurodegeneratives, Corea de Huntington

Matèries (anglès)

Cerebral cortex, Neurodegenerative Diseases, Huntington's chorea

Citació

Col·leccions

Articles publicats en revistes (Biomedicina)

Citació

SOLANA BALAGUER, Júlia, GARCIA-SEGURA, Pol, CAMPOY CAMPOS, Genís, CHICOTE GONZÁLEZ, Almudena, FERNÁNDEZ IRIGOYEN, Joaquín, SANTAMARÍA HERNÁNDEZ, Esther, PÉREZ NAVARRO, Esther, MASANA NADAL, Mercè, ALBERCH I VIÉ, Jordi, MALAGELADA GRAU, Cristina. Motor skill learning modulates striatal extracellular vesicles’ content in a mouse model of Huntington’s disease. _Cell Communication and Signaling_. 2024. Vol. 22, núm. 1. [consulta: 25 de febrer de 2026]. ISSN: 1478-811X. [Disponible a: https://hdl.handle.net/2445/221899]

Exportar metadades

JSON - METS

Compartir registre