Breast Cancer in Men: Clinical and Pathological Analysis of 19 Cases and Review of Literature

Abstract

Background: Breast cancer (BC) in men is an uncommon disease lacking studies and specific recommendations on clinical guidelines focused on this group of patients. During the last years there have been an increase of cases of BC in this subgroup, and some studies suggest that differences between both genders. Objective: To describe a cohort of male patients with BC, to evaluate its clinical characteristics, surgery approach and to review and discus critical points on male BC. Methods: In this cross-sectional study the electronic data was collected retrospectively for the selected cases between April 2010 and June 2020. A descriptive analysis of the data and the recurrence Kaplan Meyer curve were performed. Results: A total of 19 cases were recorded. The mean age was 65.2 years (±12.6 SD compared with 59.2 years ±16.2 SD in women), the Body Mass Index was 28.78 ± 4.9 SD, with 31.6% of cases diagnosed with gynecomastia. In all cases treated with surgery, the surgical treatment of choice was mastectomy. The average tumour diameter was 23.58mm. The immunohistochemical subtypes classification was; Luminal A-like 26.32%, Luminal B-like Her2 negative 52.63%, Luminal B-like Her2 positive 15.79%, Triple negativelike 5.26%, Her2 pure-like 0%. Conclusion: The mean age of male BC patients is greater than that observed in women, with a higher rate of luminal histological subtypes and a more aggressive surgical approach. Due to being underrepresented or even excluded in most of the studies, today there are no-evidence to make the best approach in the management of these patients.