Large-scale evidence for the effect of the COL1A1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study

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dc.contributor.authorRalston, Stuart H.
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorBrandi, Maria Luisa
dc.contributor.authorBalcells Comas, Susana
dc.contributor.authorLangdahl, Bente L.
dc.contributor.authorLips, Paul
dc.contributor.authorLorenc, Roman
dc.contributor.authorObermayer-Pietsch, Barbara
dc.contributor.authorScollen, Serena
dc.contributor.authorBustamante Pineda, Mariona
dc.contributor.authorBjerre Husted, Lise
dc.contributor.authorCarey, Alisoun H.
dc.contributor.authorDíez Pérez, Adolfo
dc.contributor.authorDunning, Alison M.
dc.contributor.authorFalchetti, Alberto
dc.contributor.authorKarczmarewicz, Elzbieta
dc.contributor.authorKruk, Marcin
dc.date.accessioned2013-05-08T13:52:46Z
dc.date.available2013-05-08T13:52:46Z
dc.date.issued2006-04
dc.date.updated2013-05-08T13:52:46Z
dc.description.abstractOsteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for low bone mineral density (BMD) and osteoporotic fracture, but there have been no very-large-scale studies of COLIA1 alleles in relation to these phenotypes.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec545336
dc.identifier.issn1549-1277
dc.identifier.urihttps://hdl.handle.net/2445/43234
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pmed.0030090
dc.relation.ispartofPLoS Medicine, 2006, vol. 3, num. 4, p. 515-523
dc.relation.urihttp://dx.doi.org/10.1371/journal.pmed.0030090
dc.rightscc-by (c) Ralston, S.H. et al., 2006
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Genètica, Microbiologia i Estadística)
dc.subject.classificationOsteoporosi
dc.subject.classificationGenòmica
dc.subject.classificationDensitometria òssia
dc.subject.otherOsteoporosis
dc.subject.otherGenomics
dc.subject.otherBone densitometry
dc.titleLarge-scale evidence for the effect of the COL1A1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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