Document type
ArticleVersion
Accepted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/218091
Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
INTRODUCTION: miRNAs are small non-coding RNAs, some of which are expressed in adipose tissues, are present in the circulation, and are regulated in obesity. Bariatric surgery (BS) has been proposed to lead to activation of brown adipose tissue, an effect that may be related to beneficial effects of BS on systemic metabolism. Here, we evaluated circulating levels of miR-92a and miR-99b, two miRNAs proposed as biomarkers of brown fat activity, in a cohort of patients with severe obesity before and after BS, and studied their potential relationship with BS-associated improvements in metabolic parameters. METHODS: Circulating levels of miR-92a and miR-99b were quantified in a cohort of 26 patients (age, 48 ± 10 years; BMI, 45 ± 7 kg/m2) before and 6 months after BS. Clinical parameters were determined at different time points and correlations among them were studied. RESULTS: Basal levels of miR-92a were significantly increased in patients with obesity relative to lean controls. Serum miR-92a levels were strongly reduced at 6 months after BS, reaching levels similar to those in controls. Serum miR-99b levels were unchanged in relation to both the obese condition and BS. Elevated levels of miR-92a were directly correlated with worsened glucose homeostasis parameters and poor BS outcome. CONCLUSIONS: Our findings show that miR-92a is elevated in conditions of obesity, and its reduction after BS correlates with metabolic improvement. Further studies would be necessary to establish miR-92a as serum biomarker and potential predictor of the BS success in improving the metabolic status of patients with obesity.
Subject
Subject (English)
Citation
Citation
CEREIJO TÉLLEZ, Rubén, et al. Elevated levels of circulating miR-92a are associated with impaired glucose homeostasis in patients with obesity and correlate with metabolic status after bariatric burgery. Obesity Surgery. 2020. Vol. 30, num. 1, pags. 174-179. ISSN 0960-8923. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/218091