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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/117488
Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium
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Epigenetics refers to mitotically heritable changes to the DNA, which do not affect the DNA sequence, but can influence its function. Currently, DNA methylation is the most studied epigenetic phenomenon in large populations. It entails the binding of a methyl group, mainly to positions in genomic DNA where a cytosine is located next to a guanine, a cytosine-phosphate-guanine (CpG) site (Figure 1). DNA methylation at CpG sites can influence gene expression by altering the DNA’s three-dimensional structure and interacting with methyl-binding proteins, consequently affecting the binding of the gene transcription and chromatin-modifying machinery. There are approximately 28 million CpG sites in the human genome. DNA methylation is a dynamic process that can be influenced by genetic factors, as well as by environmental factors such as diet, air pollution, toxicants or smoking.1–4 Hence, DNA methylation may be seen as linking the genome to the environment with respect to health and disease. Early development is a period of profound changes in DNA methylation and may, as such, be a critical period for environmentally-induced DNA methylation changes.4 Hence, this period is of specific interest for DNA methylation studies in relation to specific exposures and long-term health outcomes
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FELIX, Janine f., JOUBERT, Bonnie r., BACCARELLI, Andrea a., SHARP, Gemma c., ALMQVIST, Catarina, ANNESI-MAESANO, Isabella, ARSHAD, Hasan, BAIZ, Nour, BAKERMANS-KRANENBURG, Marian j., BAKULSKI, Kelly m., BINDER, Elisabeth b., PLUSQUIN, Michelle, TIEMEIER, Henning, RAIKKONEN, Katri, RZEHAK, Peter, WANG, Pei, REESE, Sarah e., REISCHL, Eva, RICHIARDI, Lorenzo, RING, Susan m., SCHWARTZ, David a., WIEMELS, Joseph l., TAYLOR, Jack a., YOUSEFI, Paul, SEBERT, Sylvain, SNIEDER, Harold, SORENSEN, Thorkild i. a., STARLING, Anne p., ULLEMAR, Vilhelmina, ZHANG, Weiming, VAFEIADI, Marina, BOUCHARD, Luigi, BRUNEKREEF, Bert, VAN IJZENDOORN, Marinus h., VONK, Judith m., VRIENS, Annette, VRIJHEID, Martine, WILCOX, Allen j., ZHANG, Hongmei, CZAMARA, Darina, WRIGHT, Rosalind j., XU, Cheng-jian, XU, Zongli, YANG, Ivana v., ZHAO, Shanshan, DAVEY SMITH, George, BRETON, Carrie v., EVERSON, Todd m., AGHA, Golareh, RELTON, Caroline l., JADDOE, Vincent w., LONDON, Stephanie j., BRUNST, Kelly j., FALLIN, M. daniele, BURCHARD, Esteban g., DABELEA, Dana, GONSETH, Semira, BUSTAMANTE PINEDA, Mariona, CHATZI, Leda, CHENG MUNTHE-KAAS, Monica, CORPELEIJN, Eva, DE BOEVER, Patrick, FALAHI, Fahimeh, HOLLOWAY, John w., DUIJTS, Liesbeth, DWYER, Terence, ENG, Celeste, ESKENAZI, Brenda, FARCHI, Sara, HU, Donglei, FERNANDEZ, Mariana f., KARAGAS, Margaret r., GAO, Lu, GAUNT, Tom r., GHANTOUS, Akram, GILLMAN, Matthew w., GROTE, Veit, KARMAUS, Wilfried, GRUZIEVA, Olena, HOYO, Cathrine, LADD-ACOSTA, Christine, HABERG, Siri e., HERCEG, Zdenko, HIVERT, Marie-france, HOLLAND, Nina, HUANG, Rae-chi, KARLSSON, Robert, MAGNUS, Per, HUEN, Karen, JARVELIN, Marjo-riitta, JIMA, Dereje d., JUST, Allan c., KECHRIS, Katerina j., MARSIT, Carmen j., KERE, Juha, NISTICO, Lorenza, KOGEVINAS, Manolis, KOLETZKO, B. (berthold), KOPPELMAN, Gerard h., KUPERS, Leanne k., LAHTI, Jari, NORDLUND, Bjorn, LAMBRECHTS, Nathalie, MAGUIRE, Rachel l., PIZZI, Costanza, LANGIE, Sabine a. s., LIE, Rolv t., LIU, Andrew h., MAGNUS, Maria c., MCARDLE, Wendy, NOHR, Ellen aagard, ROY, Ritu, MELÉN, Erik, MELTON, Phillip e., MURPHY, Susan k., NAWROT, Tim s., NYSTAD, Wenche, SCHOETERS, Greet, OH, Sam s., SUNYER DEU, Jordi, OKEN, Emily, PAGE, Christian magnus, PERRON, Patrice, PERSHAGEN, Göran. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE)
Consortium. _International Journal of Epidemiology_. 2017. pàgs. Ahead of print. [consulta: 24 de gener de 2026]. ISSN: 0300-5771. [Disponible a: https://hdl.handle.net/2445/117488]