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Optimized N-methyl-D-aspartate receptor antagonist exhibits hippocampal proneurogenic effects in aged senescence-accelerated mouse prone 8 mice
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N-methyl-D-aspartate (NMDA) receptor antagonists mediate adult neurogenic effects. Here, the neurogenic effect of a new NMDA receptor antagonist endowed with neuroprotective effects in Alzheimer's disease mice model. Nine-month-old senescence-accelerated mouse prone 8 (SAMP8) with UB-ALT-EV were orally treated. 5-Bromo-2-deoxyuridine (BrdU) (50 mg/kg) was 3× injected I.P. every 2 h. After 28 days of treatment, SAMP8-treated group improved working memory. Moreover, the number of BrdU+ cells and DCX+ cells in the SAMP8 dentate gyrus (DG) was significantly increased. GFAP+ cells were not affected by treatment. Together, these results provided evidence that UB-ALT-EV promotes the survival and proliferation of neural progenitor cells in the aged SAMP8 hippocampus.
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COMPANYS ALEMANY, Júlia, ROIG-SORIANO, Joan, TURCU, Andreea l., CHILLÓN, Miguel, VÁZQUEZ CRUZ, Santiago, PALLÀS I LLIBERÍA, Mercè, GRIÑÁN FERRÉ, Christian. Optimized N-methyl-D-aspartate receptor antagonist exhibits hippocampal proneurogenic effects in aged senescence-accelerated mouse prone 8 mice. _NeuroReport_. 2022. Vol. 33, núm. 4, pàgs. 623-628. [consulta: 7 de febrer de 2026]. ISSN: 0959-4965. [Disponible a: https://hdl.handle.net/2445/189684]