Miniatura

Fitxers

730207.pdf (530.51 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2022-05-01

Llicència de publicació

cc-by-nc-nd (c) Moreno García, Estela et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/198568

Bacterial co-infection at hospital admission in patients with COVID-19

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1016/j.ijid.2022.03.003

Resum

Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19. Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February 2020-February 2021). All patients with COVID-19 who were admitted for >48 hours with microbiological sample collection and procalcitonin (PCT) determination within the first 48 hours were included. Results: A total of 1125 consecutive adults met inclusion criteria. Co-infections were microbiologically documented in 102 (9.1%) patients. Most frequent microorganisms were Streptococcus pneumoniae (79%), Staphylococcus aureus (6.8%), and Haemophilus influenzae (6.8%). Test positivity was 1% (8/803) for blood cultures, 10.1% (79/780) for pneumococcal urinary antigen test, and 11.4% (15/132) for sputum culture. Patients with PCT higher than 0.2, 0.5, 1, and 2 ng/mL had significantly more co-infections than those with lower levels (p=0.017, p=0.031, p<0.001, and p<0.001, respectively). In multivariate analysis, oxygen saturation ≤94% (OR 2.47, CI 1.57-3.86), ferritin levels <338 ng/mL (OR 2.63, CI 1.69-4.07), and PCT higher than 0.2 ng/mL (OR 1.74, CI 1.11-2.72) were independent risk factors for co-infection at hospital admission owing to COVID-19. Conclusions: Bacterial co-infection in patients hospitalized for COVID-19 is relatively common. However, clinicians could spare antibiotics in patients with PCT values <0.2, especially with high ferritin values and oxygen saturation >94%.

Matèries

SARS-CoV-2, COVID-19, Antibiòtics, Malalties bacterianes, Infeccions per coronavirus, Malalts hospitalitzats

Matèries (anglès)

SARS-CoV-2, COVID-19, Antibiotics, Bacterial diseases, Coronavirus infections, Hospital patients

Citació

Col·leccions

Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (ISGlobal)

Citació

MORENO GARCÍA, Estela, PUERTA-ALCALDE, Pedro, LETONA GIMÉNEZ, Laura, MEIRA, Fernanda, DUEÑAS, Gerard, CHUMBITA, Mariana, GARCÍA POUTON, Nicole, MONZÓ GALLO, Patricia, LOPERA, Carlos, SERRA, Laia, CARDOZO ESPINOLA, Celia, HERNÁNDEZ-MENESES, Marta, RICO, Verónica, BODRO, Marta, MORATA, Laura, FERNÁNDEZ PITTOL, Mariana josé, GRAFIA, Ignacio, CASTRO, Pedro, MENSA PUEYO, Josep, MARTÍNEZ, José antonio, SANJUAN, Gemma, MARCOS, Ma. angeles, SORIANO VILADOMIU, Alex, GARCIA VIDAL, Carolina, Hospital Clinic of Barcelona COVID-19 Research Group. Bacterial co-infection at hospital admission in patients with COVID-19. _International Journal of Infectious Diseases_. 2022. Vol. 118, núm. 197-202. [consulta: 8 de febrer de 2026]. ISSN: 1201-9712. [Disponible a: https://hdl.handle.net/2445/198568]

Exportar metadades

JSON - METS

Compartir registre