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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/179918
Melanogenesis and Melasma Treatment
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Abstract
Melanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in subcellular lysosome-like organelles called melanosomes, where melanin is synthesised and stored. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair, and eyes of mammals. The regulation of melanogenesis includes various mechanisms and factors including genetic, environmental, and endocrine factors. Knowledge of the pigmentation process is important not only to understand hyperpigmentation but also to design treatments and therapies to treat them. Whitening cosmetics with anti-melanogenesis activity are very popular. In the present manuscript, we review the mechanisms and the signalling pathways involved in skin pigmentation and we specifically focus on the alteration of melanogenesis that leads to melasma and results in hyperpigmentation. Finally, current therapies and treatments including topical, oral, and phototherapies are discussed and described, with a special emphasis on the cosmetics' action.
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SOLANGE MADDALENO, Adriana, et al. Melanogenesis and Melasma Treatment. Cosmetics. 2021. Vol. 8, num. 3, pags. 82-93. ISSN 2079-9284. [consulted: 17 of June of 2026]. Available at: https://hdl.handle.net/2445/179918