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630101.pdf (521.19 KB)

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Data de publicació

2012-07-11

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cc-by (c) Almendros López, Isaac et al., 2012
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/138678

Potential role of adult stem cells in obstructive sleep apnea

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Recurs relacionat

https://doi.org/10.3389/fneur.2012.00112

Resum

Adult stem cells are undifferentiated cells that can be mobilized from the bone marrow or other organs, home into injured tissues, and differentiate into different cell phenotypes to serve in a repairing capacity. Furthermore, these cells can respond to inflammation and oxidative stress by exhibiting immunomodulatory properties. The protective and reparative roles of mesenchymal stem cells (MSCs), very small embryonic-like stem cells (VSELs), and endothelial progenitor cells (EPCs) have primarily been examined and characterized in auto-immune and cardiovascular diseases. Obstructive sleep apnea (OSA) is a very prevalent disease (4-5% of adult population and 2-3% of children) characterized by an abnormal increase in upper airway collapsibility. Recurrent airway obstructions elicit arterial oxygen desaturations, increased inspiratory efforts, and sleep fragmentation, which have been associated with important long-term neurocognitive, metabolic, and cardiovascular consequences. Since inflammation, oxidative stress and endothelial dysfunction are key factors in the development of the morbid consequences of OSA, bone marrow-derived stem cells could be important modulators of the morbid phenotype by affording a protective role. This mini-review is focused on the recent data available on EPCs, VSELs, and MSCs in both animal models and patients with OSA.

Matèries

Síndromes d'apnea del son, Cèl·lules mare

Matèries (anglès)

Sleep apnea syndromes, Stem cells

Citació

Col·leccions

Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citació

ALMENDROS LÓPEZ, Isaac, et al. Potential role of adult stem cells in obstructive sleep apnea. Frontiers In Neurology. 2012. Vol. 3. ISSN 1664-2295. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/138678

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