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Kumar_Science_2024_preprint2.pdf (3.1 MB)

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Data de publicació

2024-05-02

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/213647

Brain-muscle communication prevents muscle aging by maintaining daily physiology

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Recurs relacionat

https://doi.org/10.1126/science.adj8533

Resum

A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions.

Matèries

Envelliment, Homeòstasi

Matèries (anglès)

Aging, Homeostasis

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Col·leccions

Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citació

KUMAR, Arun, et al. Brain-muscle communication prevents muscle aging by maintaining daily physiology. Science. 2024. Vol. 384, num. 6695, pags. 563-572. ISSN 1095-9203. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/213647

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