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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/199873
Comparison of MRI Spectroscopy software packages performance and application on HCV-infected patients’ real data
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1H MRS is conceived as a pioneer methodology for brain metabolism inspection and health status
appraisal. Post-processing interventions are required to obtain explicit metabolite quantification
values from which to derive diagnosis. On the grounds of addressing and covering such operation,
multiple software packages have been recently developed and launched leading to an amorphous
assortment of spectroscopic image processing tools, with lack of standardization and regulation.
The current study thereby intends to judge the coherence and consistency of compound estimation
outputs in terms of result variability by intercorrelation and intracorrelation analyses between
appointed programs, being LCModel, Osprey, TARQUIN, and spant toolbox. The examination is
performed on a 83-subject SVS short-TE 3T SIEMENS PRESS spectroscopic acquisitions’
collection, including healthy controls and HCV-infected patients assisted with DAA treatment. The
analytical core of the project assesses software performance through the creation of a Python script
in order to automatically compute and display the results sought. The statistical tests providing
enough information to draw substantial conclusions stem from extraction of coefficient of
determination (R2
), Pearson’s coefficient (r), and intraclass correlation coefficient (ICC) together
with representation of boxplots, rainclouds, and scatter plots easing data visualization. A clinical
implementation is also entailed on the same basis, whose purpose is to reveal actual DAA
treatment effect on HCV-infected patients by means of metabolite concentration alteration and
hypothetical restoration. Conclusions declare evident and alarming variability among MRS
platforms compromising the rigor, sharpness and systematization demanded in this discipline since
quantification results hold incoherences, although they do not seem to affect or oppose medical
determinations jeopardizing patient’s health. However, it would be interesting to extend the analysis
to a greater cohort of subjects to reinforce and get to more solid resolutions.
Descripció
Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2022-2023. Tutor/Director: Sala Llonch, Roser, Laredo Gregorio, Carlos
Matèries (anglès)
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NICOLAU GRAUPERA, Carla. Comparison of MRI Spectroscopy software packages performance and application on HCV-infected patients’ real data. [consulta: 23 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/199873]