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722960.pdf (1.83 MB)

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2020

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(c) Touceda-Suárez, María et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/192202

Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications

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Recurs relacionat

https://doi.org/10.1093/molbev/msaa123

Resum

We investigated how the two rounds of whole genome duplication that occurred at the base of the vertebrate lineage have impacted ancient microsyntenic associations involving developmental regulators (known as genomic regulatory blocks, GRBs). We showed that the majority of GRBs identified in the last common ancestor of chordates have been maintained as a single copy in humans. We found evidence that dismantling of the duplicated GRB copies occurred early in vertebrate evolution often through the differential retention of the regulatory gene but loss of the bystander gene's exonic sequences. Despite the large evolutionary scale, the presence of duplicated highly conserved non-coding regions provided unambiguous proof for this scenario for multiple ancient GRBs. Remarkably, the dismantling of ancient GRB duplicates has contributed to the creation of large gene deserts associated with regulatory genes in vertebrates, providing a potentially widespread mechanism for the origin of these enigmatic genomic traits.

Matèries

Genòmica, Vertebrats

Matèries (anglès)

Genomics, Vertebrates

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citació

TOUCEDA-SUÁREZ, María, KITA, Elizabeth m., ACEMEL, Rafael d., FIRBAS, Panos n., MAGRI, Marta s., NARANJO, Silvia, TENA, Juan j., GÓMEZ-SKARMETA, Jose luis, MAESO, Ignacio, IRIMIA MARTÍNEZ, Manuel. Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications. _Molecular Biology and Evolution_. 2020. Vol. 37, núm. 10, pàgs. 2857-2864. [consulta: 7 de gener de 2026]. ISSN: 0737-4038. [Disponible a: https://hdl.handle.net/2445/192202]

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