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Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts
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Background
The extent to which airflow obstruction, a key feature of COPD, can be already present in early adulthood is unclear. We investigated the prevalence of airflow obstruction in young adults across European populations.
Methods
We identified 48 612 individuals aged 20–40 years across eight population-based European cohorts in the Chronic Airway Diseases Early Stratification (CADSET) collaboration and applied two commonly used definitions of airflow obstruction: pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.70 and below the lower limit of normal (LLN). We explored how the prevalence of airflow obstruction according to both criteria was related to age, sex and smoking.
Results
Airflow obstruction prevalence increased with increasing age from 2.3% in those aged 20–24.9 years to 6.3% in those aged 35–39.9 years according to FEV1/FVC <0.70, and from 7.3% to 8.3% according to FEV1/FVC
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ÇOLAK, Yunus, et al. Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts. ERJ Open Research. 2025. Vol. 11, núm. 6. ISSN 2312-0541. [consulta: 12 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/227551