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Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis
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The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.
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FERRER, Isidro (ferrer abizanda), TUÑÓN, Teresa, SERRANO PIÑOL, M. teresa, CASAS, Rosaura, ALCÁNTARA HORRILLO, Soledad, ZÚJAR, M. j., RIVERA, R. m.. Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis. _Journal of Neurology Neurosurgery and Psychiatry_. 1993. Vol. 56, núm. 257-261. [consulta: 30 de gener de 2026]. ISSN: 0022-3050. [Disponible a: https://hdl.handle.net/2445/25546]