Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Synthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones

Vista senzilla d'ítem
dc.contributor.authorDiaba, Faïza
dc.contributor.authorMontiel Achong, Juan Andrés
dc.contributor.authorSerban, Georgeta
dc.contributor.authorBonjoch i Sesé, Josep
dc.date.accessioned2019-02-18T10:49:20Z
dc.date.available2019-02-18T10:49:20Z
dc.date.issued2015-01-21
dc.date.updated2019-02-18T10:49:20Z
dc.description.abstractAn unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-type reaction of trichloroacetamides promoted by enamines (generated in situ from ketones) as counter-reagents. The methodology was applied to the synthesis of compounds embodying the 6-azabicyclo[3.2.1]octane framework.
dc.format.extent4 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec654621
dc.identifier.issn1523-7060
dc.identifier.pmid26197207
dc.identifier.urihttps://hdl.handle.net/2445/128365
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.5b01832
dc.relation.ispartofOrganic Letters, 2015, vol. 2015, num. 17, p. 3860-3863
dc.relation.urihttps://doi.org/10.1021/acs.orglett.5b01832
dc.rights(c) American Chemical Society , 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationCetones
dc.subject.classificationAmines
dc.subject.classificationSíntesi orgànica
dc.subject.classificationReaccions químiques
dc.subject.otherKetones
dc.subject.otherAmines
dc.subject.otherOrganic synthesis
dc.subject.otherChemical reactions
dc.titleSynthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

Fitxers

Paquet original

Mostrant 1 - 1 de 1
Miniatura
Nom:
654621.pdf
Mida:
784.7 KB
Format:
Adobe Portable Document Format
Descarregar

Col·leccions

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))