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2005-07-26

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/179303

Epigenetic differences arise during the lifetime of monozygotic twins

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https://doi.org/10.1073/pnas.0500398102

Resum

Monozygous twins share a common genotype. However, most monozygotic twin pairs are not identical; several types of phenotypic discordance may be observed, such as differences in susceptibilities to disease and a wide range of anthropomorphic features. There are several possible explanations for these observations, but one is the existence of epigenetic differences. To address this issue, we examined the global and locus-specific differences in DNA methylation and histone acetylation of a large cohort of monozygotic twins. We found that, although twins are epigenetically indistinguishable during the early years of life, older monozygous twins exhibited remarkable differences in their overall content and genomic distribution of 5-methylcytosine DNA and histone acetylation, affecting their gene-expression portrait. These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype.

Matèries

ADN, Expressió gènica, Histones, Fenotip, Bessons

Matèries (anglès)

DNA, Gene expression, Histones, Phenotype, Twins

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Articles publicats en revistes (Ciències Fisiològiques)

Citació

FRAGA, Mario f., BALLESTAR TARÍN, Esteban, PAZ, Maria f., ROPERO, Santiago, SETIÉN, Fernando, BALLESTER PALACIOS, M. l. (maria lluïsa), HEINE SUÑER, Damià, CIGUDOSA, Juan cruz, URIOSTE, Miguel, BENITEZ, Javier, BOIX-CHORNET, Manuel, SÁNCHEZ-AGUILERA, Abel, LING, Charlotte, CARLSSON, Emma, POULSEN, Pernille, VAAG, Allan, STEPHAN, Zarko, SPECTOR, Tim d., WU, Yue-zhong, PLASS, Christoph, ESTELLER, Manel. Epigenetic differences arise during the lifetime of monozygotic twins. _Proceedings of the National Academy of Sciences of the United States of America - PNAS_. 2005. Vol. 102, núm. 30, pàgs. 10604-10609. [consulta: 24 de gener de 2026]. ISSN: 0027-8424. [Disponible a: https://hdl.handle.net/2445/179303]

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