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Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization

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dc.contributor.authorHernández Romero, Delia
dc.contributor.authorRiego, Estela
dc.contributor.authorFrancesch, Andrés
dc.contributor.authorCuevas, Carmen
dc.contributor.authorAlbericio Palomera, Fernando
dc.contributor.authorÁlvarez Domingo, Mercedes
dc.date.accessioned2014-06-27T08:22:41Z
dc.date.available2014-06-27T08:22:41Z
dc.date.issued2007-07-10
dc.date.updated2014-06-27T08:22:41Z
dc.description.abstractHerein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis. The macrocyclization of rigid peptide compounds 1 and 2 to give IB-01211 and its epimer 12b was explored, and the results are compared here to those previously obtained for the macrocyclization of more flexible structures in the syntheses of YM-216391, telomestatin, and IB-01211. Lastly, the preliminary results of anti-tumor activity screening of the synthesized analogs are discussed.
dc.format.extent9 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec555878
dc.identifier.issn0040-4020
dc.identifier.urihttps://hdl.handle.net/2445/55267
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1016/j.tet.2007.06.103
dc.relation.ispartofTetrahedron, 2007, vol. 63, num. 39, p. 9862-9870
dc.relation.urihttp://dx.doi.org/10.1016/j.tet.2007.06.103
dc.rights(c) Elsevier B.V., 2007
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationProductes naturals
dc.subject.classificationPèptids
dc.subject.classificationSíntesi orgànica
dc.subject.classificationCompostos heterocíclics
dc.subject.otherNatural products
dc.subject.otherPeptides
dc.subject.otherOrganic synthesis
dc.subject.otherHeterocyclic compounds
dc.titlePreparation of penta-azole containing cyclopeptides: challenges in macrocyclization
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)