Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/162312
Functional effects of the buckwheat iminosugar D-fagomine on rats with diet-induced prediabetes
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Scope: The goals of this work were to test if D-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action. Methods and results: Wistar Kyoto rats were fed a high-fat diet supplemented with D7 fagomine (or not; for comparison) or a standard diet (controls) for 24 weeks. The variables measured were: fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue, liver and muscle; inflammation markers (plasma IL-6 and leptin, and liver and adipose tissue histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales and Bifidobacteriales in feces. We found that D-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 and leukotriene B4) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales. Conclusion: D-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of D-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria.
Matèries
Matèries (anglès)
Citació
Citació
RAMOS ROMERO, Sara, HEREU, Mercè, ATIENZA, Lidia, CASAS, Josefina, TALTAVULL, Núria, ROMEU FERRAN, Marta, AMÉZQUETA, Susana, DASILVA, Gabriel, MEDINA, Isabel, TORRES, Josep lluís. Functional effects of the buckwheat iminosugar D-fagomine on rats with diet-induced prediabetes. _Molecular Nutrition & Food Research_. 2018. Vol. 62, núm. 16, pàgs. 1800373. [consulta: 25 de febrer de 2026]. ISSN: 1613-4125. [Disponible a: https://hdl.handle.net/2445/162312]