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Article

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2009

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/22470

Rituximab therapy for refractory systemic-onset juvenile idiopathic arthritis.

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http://dx.doi.org/10.1136/ard.2008.092106

Abstract

Systemic-onset juvenile idiopathic arthritis (SOJIA), formerly called Still’s disease, is a subset of juvenile arthritis that describes patients with fever, rash, arthritis, serositis and visceromegaly. In up to 30% of cases the disease has a chronic course and management requires high doses of glucocorticoids, disease-modifying antirheumatic drugs (DMARD), tumour necrosis factor alpha (TNFα) inhibitors or anakinra.1–6 However, this therapeutic arsenal is unable to control the disease in all patients.#N##N#Recently, rituximab, a chimeric anti-CD20 monoclonal antibody, has been successfully used in two patients with refractory adult-onset Still’s disease.7 As the similarity of clinical and laboratory features present in SOJIA and adult-onset Still’s disease implies that these conditions have similar …

Subject

Artritis, Joves, Terapèutica

Subject (English)

Arthritis, Youth, Therapeutics

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Articles publicats en revistes (Ciències Clíniques)

Citation

NARVÁEZ GARCÍA, Francisco Javier, et al. Rituximab therapy for refractory systemic-onset juvenile idiopathic arthritis. Annals of the Rheumatic Diseases. 2009. Vol. 68, num. 4, pags. 607-608. ISSN 0003-4967. [consulted: 9 of August of 2026]. Available at: https://hdl.handle.net/2445/22470

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