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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/69256
Accuracy of an HRP-2/panLDH rapid diagnostic test to detect peripheral and placental Plasmodium falciparum infection in Papua New Guinean women with anaemia or suspected malaria
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BACKGROUND: The diagnosis of malaria during pregnancy is
complicated by placental sequestration, asymptomatic infection,
and low-density peripheral parasitaemia. Where intermittent
preventive treatment (IPT) with sulfadoxine-pyrimethamine is
threatened by drug resistance, or is inappropriate due to low
transmission, intermittent screening and treatment (ISTp) with
rapid diagnostic tests for malaria (RDT) could be a valuable
alternative. Therefore, the accuracy of RDTs to detect
peripheral and placental infection was assessed in a declining
transmission setting in Papua New Guinea (PNG). METHODS: The
performance of a combination RDT detecting histidine-rich
protein-2 (HRP-2) and Plasmodium lactate dehydrogenase (pLDH),
and light microscopy (LM), to diagnose peripheral Plasmodium
falciparum and Plasmodium vivax infections during pregnancy,
were assessed using quantitative real-time PCR (qPCR) as the
reference standard. Participants in a malaria prevention trial
in PNG with a haemoglobin 50 % of these infections.
CONCLUSIONS: In PNG, HRP-2/pLDH RDTs may be useful to diagnose
peripheral P. falciparum infections in symptomatic pregnant
women. However, they are not sufficiently sensitive for use in
intermittent screening amongst asymptomatic (anaemic) women.
These findings have implications for the management of malaria
in pregnancy. The adverse impact of infections undetected by RDT
or LM on pregnancy outcomes needs further evaluation.
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UMBERS, Alexandra j., UNGER, Holger werner, ROSANAS URGELL, Anna, WANGNAPI, Regina a., KATTENBERG, Johanna helena, JALLY, Shadrach, SILIM, Selina, LUFELE, Elvin, KARL, Stephan, OME-KAIUS, Maria, ROBINSON, Leanne j., ROGERSON, Stephen john, MUELLER, Ivo. Accuracy of an HRP-2/panLDH rapid diagnostic test to detect peripheral and placental Plasmodium falciparum infection in Papua New Guinean women with anaemia or suspected malaria. _Malaria Journal_. 2015. Vol. 14, núm. 412, pàgs. 1-11. [consulta: 25 de febrer de 2026]. ISSN: 1475-2875. [Disponible a: https://hdl.handle.net/2445/69256]