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2020-10-16

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/214976

Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.

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https://doi.org/10.1126/science.aay8085

Resum

Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection.

Matèries

Teixit adipós, Immunologia, Bacteris, Metabolisme cel·lular

Matèries (anglès)

Adipose tissues, Immunology, Bacteria, Cell metabolism

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

BOSCH, Marta, SÁNCHEZ ÁLVAREZ, Miguel, FAJARDO, Alba, KAPETANOVIC, Ronan, STEINER, Bernhard, DUTRA, Filipe, MOREIRA, Luciana, LÓPEZ, Juan antonio, CAMPO, Rocío, MARÍ, Montserrat, MORALES PAYTUVI, Frederic, TORT, Olivia, GUBERN, Albert, TEMPLIN, Rachel m., CURSON, James e. b., MARTEL, Nick, CATALÀ, Cristina, LOZANO, Francisco, TEBAR RAMON, Francesc, ENRICH BASTÚS, Carles, VÁZQUEZ, Jesús, DEL POZO, Miguel angel, SWEET, Matthew j., BOZZA, Patricia t., GROSS, Steven p., PARTON, Robert g., POL I SOROLLA, Albert. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.. _Science_. 2020. Vol. 370, núm. 6514. [consulta: 25 de febrer de 2026]. ISSN: 0036-8075. [Disponible a: https://hdl.handle.net/2445/214976]

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