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2019-12-01

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cc-by (c) Bautista, et. al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/172291

ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain

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https://doi.org/10.1007/s12094-019-02221-9

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Introduction: Cancer and blood disorders in children are rare. The progressive improvement in survival over the last decades largely relies on the development of international academic clinical trials that gather the sufcient number of patients globally to elaborate solid conclusions and drive changes in clinical practice. The participation of Spain into large international academic trials has traditionally lagged behind of other European countries, mainly due to the burden of administrative tasks to open new studies, lack of fnancial support and limited research infrastructure in our hospitals. Methods: The objective of ECLIM-SEHOP platform (Ensayos Clínicos Internacionales Multicéntricos-SEHOP) is to overcome these difculties and position Spain among the European countries leading the advances in cancer and blood disorders, facilitate the access of our patients to novel diagnostic and therapeutic approaches and, most importantly, continue to improve survival and reducing long-term sequelae. ECLIM-SEHOP provides to the Spanish clinical investigators with the necessary infrastructural support to open and implement academic clinical trials and registries. Results: In less than 3 years from its inception, the platform has provided support to 20 clinical trials and 8 observational studies, including 8 trials and 4 observational studies where the platform performs all trial-related tasks (integral support: trial setup, monitoring, etc.) with more than 150 patients recruited since 2017 to these studies. In this manuscript, we provide baseline metrics for academic clinical trial performance that permit future comparisons. Conclusions: ECLIM-SEHOP facilitates Spanish children and adolescents diagnosed with cancer and blood disorders to access state-of-the-art diagnostic and therapeutic strategies.

Matèries

Oncologia pediàtrica, Assaigs clínics, Desenvolupament de medicaments

Matèries (anglès)

Tumors in children, Clinical trials, Drug development

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

Citació

BAUTISTA, F., CANETE, A., RAMIREZ-VILLAR, G. l., FERNANDEZ, J. m., FUSTER, J. l., DIAZ DE HEREDIA, C., ASTIGARRAGA, Itziar, GARCIA-ARIZA, M., RIVES SOLÀ, Susana, DAPENA, J. l., MARQUEZ, C., MOLINES, A., BERMUDEZ, M. del m., GALLEGO, S., ANDRES, M. del m., VERDU-AMOROS, J., HERNANDEZ, C., LOPEZ, M., CATALÀ TEMPRANO, Albert, LASSALETTA, A., CRUZ MARTÍNEZ, Ofelia, RAMIREZ, M., LENDINEZ, F., CARBONE, A., GOMEZ SIRVENT, J., TALLON, M., ACHA, T., MORENO, L., FERNANDEZ-TEIJEIRO, A., Sociedad Española de Hematología y Oncología Pediá. ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain. _Clinical & Translational Oncology_. 2019. Vol. 21, núm. 12, pàgs. 1763-1770. [consulta: 31 de gener de 2026]. ISSN: 1699-048X. [Disponible a: https://hdl.handle.net/2445/172291]

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