Document type
ArticleVersion
Published versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/134469
Recovery of Free Energy Branches in Single Molecule Experiments
Journal Title
Director/Tutor
Additional contribution
Journal ISSN
Volume Title
Abstract
We present a method for determining the free energy of coexisting states from irreversible work measurements. Our approach is based on a fluctuation relation that is valid for dissipative transformations in partially equilibrated systems. To illustrate the validity and usefulness of the approach, we use optical tweezers to determine the free energy branches of the native and unfolded states of a two-state molecule as a function of the pulling control parameter. We determine, within 0.6 k B T accuracy, the transition point where the free energies of the native and the unfolded states are equal.
Related resource
Subject
Subject (English)
Citation
Citation
JUNIER, Ivan, et al. Recovery of Free Energy Branches in Single Molecule Experiments. Physical Review Letters. 2009. Vol. 102, num. 7, pags. 070602. ISSN 0031-9007. [consulted: 6 of October of 2026]. Available at: https://hdl.handle.net/2445/134469