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2019-10-04

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Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus

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https://doi.org/10.2217/epi-2018-0206

Resum

Aim: Gestational diabetes mellitus (GDM) has been linked with adverse long-term health outcomes for the fetus and mother. These effects may be mediated by epigenetic modifications. Materials & methods: Genome-wide RNA sequencing was performed in placental tissue and maternal blood in six GDM and six non-GDM pregnancies. Promoter region DNA methylation was examined for selected genes and correlated with gene expression to examine an epigenetic modulator mechanism. Results: Reductions of mRNA expression and increases in promoter methylation were observed for G6PD in GDM women, and for genes encoding IGF-binding proteins in GDM-exposed placenta. Conclusion: GDM involves epigenetic attenuation of G6PD, which may lead to hyperglycemia and oxidative stress, and the IGF-axis, which may modulate fetal macrosomia.

Matèries

Diabetis en l'embaràs, Epigenètica

Matèries (anglès)

Diabetes in pregnancy, Epigenetics

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citació

STEYN, Angela, et al. Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus. Epigenomics. 2019. Vol. 11, núm. 12. ISSN 1750-1911. [consulta: 10 de maig de 2026]. Disponible a: https://hdl.handle.net/2445/162772

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