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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/162772
Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus
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Aim: Gestational diabetes mellitus (GDM) has been linked with adverse long-term health outcomes for the fetus and mother. These effects may be mediated by epigenetic modifications. Materials & methods: Genome-wide RNA sequencing was performed in placental tissue and maternal blood in six GDM and six non-GDM pregnancies. Promoter region DNA methylation was examined for selected genes and correlated with gene expression to examine an epigenetic modulator mechanism. Results: Reductions of mRNA expression and increases in promoter methylation were observed for G6PD in GDM women, and for genes encoding IGF-binding proteins in GDM-exposed placenta. Conclusion: GDM involves epigenetic attenuation of G6PD, which may lead to hyperglycemia and oxidative stress, and the IGF-axis, which may modulate fetal macrosomia.
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STEYN, Angela, et al. Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus. Epigenomics. 2019. Vol. 11, num. 12. ISSN 1750-1911. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/162772