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2011

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/21364

Crystallization and resolution of the lipoxygenase of Pseudomonas aeruginosa 42A2 and phylogenetic study of the subfamilies of the lipoxygenases

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http://hdl.handle.net/2445/32392

Resum

Lipoxygenases are non-heme iron enzymes essential in eukaryotes, where they catalyze the formation of the fatty acid hydroperoxides that are required by a large diversity of biological and pathological processes. In prokaryotes, most of them totally lacking in polyunsaturated fatty acids, the possible biological roles of lipoxygenases have remained obscure. In this study, it is reported the crystallization of a lipoxygenase of Pseudomonas aeruginosa (Pa_LOX), the first from a prokaryote. High resolution data has been acquired which is expected to yield structural clues to the questions adressed. Besides, a preliminar phylogenetic analysis using 14 sequences has confirmed the existence of this subfamily of bacterial lipoxygenases, on one side, and a greater diversity than in the corresponding eukaryotic ones, on the other. Finally, an evolutionary study of bacterial lipoxygenases on the same set of lipoxygenases, show a selection pressure of a basically purifying or neutral character except for a single aminoacid, which would have been selected after a positive selection event.

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Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392

Matèries

Pseudomonas, Enginyeria genètica

Matèries (anglès)

Pseudomonas, Genetic engineering

Citació

Col·leccions

Llibres / Capítols de llibre (Biologia, Sanitat i Medi Ambient)
Llibres / Capítols de llibre (Bioquímica i Biomedicina Molecular)

Citació

GARRETA I GAMBÚS, Albert, CARPENA I VILELLA, Xavi, BUSQUETS ABIÓ, Montserrat, FUSTÉ MUNNÉ, M. carme, FITA RODRÍGUEZ, Ignasi, MANRESA PRESAS, Ma. ángeles (maría ángeles). Crystallization and resolution of the lipoxygenase of Pseudomonas aeruginosa 42A2 and phylogenetic study of the subfamilies of the lipoxygenases. _Recent Advances in Pharmaceutical Sciences_. 2011. Vol.  Chaper 11, núm. 247-273. [consulta: 27 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/21364]

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