Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/195590
Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
N-ethyl-pentedrone (NEPD, 2-(ethylamino)-1-phenyl-1-pentanone) is one of the latest synthetic cathinone derivatives that emerged into the illicit drug market. This drug has psychostimulant properties and has been related with several intoxications and even fatalities. However, information about the consequences of its acute and repeated consumption is lacking. Thus, the aim of our study was to investigate the behavioral effects after both acute and repeated NEPD exposure as well as the neurochemical changes. Male OF1 mice were treated with an acute dose (1, 3 or 10 mg/kg, i.p.) or received repeated injections of these doses (twice/day, 5 days) of NEPD. Shortly after drug-exposure or during drug-withdrawal, anxiety-like behavior, aggressiveness, social interaction, depressive-like symptoms, body weight and temperature were assessed. Also, monoamine synthesis enzymes, levels of neurotransmitters and their precursors and main metabolites, as well as ΔFosB, were determined in striatum and prefrontal cortex from post-mortem tissue. Acute administration of NEPD induced anxiolytic effects and reduced social exploration whereas during withdrawal after repeated administration the anxiolytic effect had vanished, and the reduced social exploration was still present and accompanied with increased aggressive behavior. Moreover, NEPD (10 mg/kg) induced slight hyperthermia and reduced weight gain during the repeated administration, whereas increased locomotor activity and lack of depressive symptoms were found during withdrawal. This was accompanied by increased plasma corticosterone and decrease in striatal dopamine. Finally, the long-lasting and robust increase in ΔFosB levels found in striatum after NEPD chronic exposure suggests a high risk of dependence. The increased aggressivity and locomotor activity, together with this potential of inducing dependence justify a warning about the risks of consumption of NEPD if translated to humans. Keywords: Addiction; Aggressive behavior; Monoamine levels; N-ethyl-pentedrone; Synthetic cathinones.
Matèries
Matèries (anglès)
Citació
Citació
ESPINOSA-VELASCO, María, REGUILÓN, Marina d., BELLOT, Marina, NADAL-GRATACÓS, Núria, BERZOSA, Xavier, GÓMEZ-CANELA, Cristian, RODRÍGUEZ-ARIAS, Marta, CAMARASA GARCÍA, Jordi, ESCUBEDO RAFA, Elena, PUBILL SÁNCHEZ, David, LÓPEZ ARNAU, Raúl. Repeated administration of N-ethyl-pentedrone induces increased aggression and impairs social exploration after withdrawal in mice. _Progress in Neuro-Psychopharmacology & Biological Psychiatry_. 2022. Vol. 117. [consulta: 24 de gener de 2026]. ISSN: 0278-5846. [Disponible a: https://hdl.handle.net/2445/195590]