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2027-01-01

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cc-by-nc (c) Pujol Solé, Nuria et al., 2027
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/231939

Ion-dependent nanomechanics and molecular organization in quatsome membranes

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Quatsomes (QS) are highly stable unilamellar nanovesicles formed by the self-assembly of quaternary ammonium surfactants and sterols. Despite their growing potential as nanocarriers, the molecular determinants of QS membrane structure and mechanics remain poorly understood, limiting the rational design of optimized formulations. Here, we investigate the effect of surfactant chain length, counterion identity, and solution ionic content on the structural and nanomechanical properties of cholesterol-based QS membranes assembled from alkyltrimethylammonium (CnTA+) salts. Supported bilayers and multilamellar membrane stacks were characterized under varying ionic conditions using atomic force microscopy (AFM), X-ray reflectivity, and molecular dynamics simulations. While surfactant chain length had only minor effects on membrane stiffness and negligible influence on fluidity, counterion identity emerged as the dominant factor governing membrane behavior. Smaller chaotropic tendence, as provided by Cl- compared to Br-, promoted tighter molecular packing, resulting in more compact, stiffer membranes with reduced fluidity and greaterresistance to AFM tip penetration. These findings highlight the critical role of ionic composition in regulating QSmembrane organization and mechanics, providing a framework for the rational design of QS-basednanomaterials.

Recurs relacionat

https://doi.org/10.1016/j.colsurfb.2026.116205

Matèries

Microscòpia de força atòmica, Estructura molecular, Dinàmica molecular

Matèries (anglès)

Atomic force microscopy, Molecular structure, Molecular dynamics

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Articles publicats en revistes (Ciència dels Materials i Química Física)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citació

PUJOL SOLÉ, Nuria, et al. Ion-dependent nanomechanics and molecular organization in quatsome membranes. Colloids and Surfaces B-Biointerfaces. 2027. Vol. 269, num. 116205. ISSN 0927-7765. [consulted: 10 of October of 2026]. Available at: https://hdl.handle.net/2445/231939

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