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2025-07-03

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cc-by-nc-nd (c) Pardo J et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/225906

Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder

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Recurs relacionat

https://doi.org/10.1038/s41531-025-01058-0

Resum

Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. Its relationship with cortical thickness (CTh), clinical features, and neuropsychological performance is also unknown. We assessed cMD and CTh in thirty-six patients with iRBD at high risk of conversion and 29 healthy controls (HC), examining associations with clinical and cognitive measures. Effect sizes were calculated using Cohen's d. Patients with iRBD showed increased cMD in rostral and caudal cortical regions compared to HC (d > 0.5). Cortical thinning was restricted to caudal areas. Higher cMD correlated with longer iRBD duration, later onset, MDS-UPDRS III, apathy, and poorer performance on Grooved Pegboard and Symbol-Digit Modality Tests. These findings suggest that cMD may be more sensitive than CTh and serve as a valuable imaging biomarker for detecting early cortical changes in prodromal LB diseases.   

Matèries

Malalties neurodegeneratives, Demència amb cossos de Lewy, Escorça cerebral

Matèries (anglès)

Neurodegenerative Diseases, Lewy body dementia, Cerebral cortex

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Col·leccions

Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

PARDO, Jèssica, ROURA, Ignacio, MONTAL, Victor, MARTÍN BARCELÓ, Cristina, OLTRA GONZÁLEZ, Javier, CAMPABADAL DELGADO, Anna, BARGALLÓ ALABART, Núria, SERRADELL, Mónica, MAYÀ CASALPRIM, Gerard, MONTINI, Angelica, GAIG, Carles, PONT SUNYER, Claustre, FORTEA, Juan, IRANZO, Alex, JUNQUÉ I PLAJA, Carme, SEGURA I FÀBREGAS, Bàrbara. Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder. _npj Parkinson's Disease_. 2025. Vol. 11, núm. 1. [consulta: 29 de gener de 2026]. ISSN: 2373-8057. [Disponible a: https://hdl.handle.net/2445/225906]

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