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709119.pdf (2.49 MB)

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2020-04-21

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cc-by (c) Mendoza, Carlos I. et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/179976

Shape selection and mis-assembly in viral capsid formation by elastic frustration

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Recurs relacionat

https://doi.org/10.7554/eLife.52525.sa2

Resum

The successful assembly of a closed protein shell (or capsid) is a key step in the replication of viruses and in the production of artificial viral cages for bio/nanotechnological applications. During self-assembly, the favorable binding energy competes with the energetic cost of the growing edge and the elastic stresses generated due to the curvature of the capsid. As a result, incomplete structures such as open caps, cylindrical or ribbon-shaped shells may emerge, preventing the successful replication of viruses. Using elasticity theory and coarse-grained simulations, we analyze the conditions required for these processes to occur and their significance for empty virus self-assembly. We find that the outcome of the assembly can be recast into a universal phase diagram showing that viruses with high mechanical resistance cannot be self-assembled directly as spherical structures. The results of our study justify the need of a maturation step and suggest promising routes to hinder viral infections by inducing mis-assembly.

Matèries

Moviment brownià, Virus, Elasticitat

Matèries (anglès)

Brownian movements, Viruses, Elasticity

Citació

Col·leccions

Articles publicats en revistes (Física de la Matèria Condensada)
Articles publicats en revistes (Institut de Recerca en Sistemes Complexos (UBICS))

Citació

MENDOZA, Carlos I. and REGUERA, D. (David). Shape selection and mis-assembly in viral capsid formation by elastic frustration. eLife. 2020. Vol. 9, num. e52525. ISSN 2050-084X. [consulted: 27 of August of 2026]. Available at: https://hdl.handle.net/2445/179976

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