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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/179976
Shape selection and mis-assembly in viral capsid formation by elastic frustration
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The successful assembly of a closed protein shell (or capsid) is a key step in the replication of viruses and in the production of artificial viral cages for bio/nanotechnological applications. During self-assembly, the favorable binding energy competes with the energetic cost of the growing edge and the elastic stresses generated due to the curvature of the capsid. As a result, incomplete structures such as open caps, cylindrical or ribbon-shaped shells may emerge, preventing the successful replication of viruses. Using elasticity theory and coarse-grained simulations, we analyze the conditions required for these processes to occur and their significance for empty virus self-assembly. We find that the outcome of the assembly can be recast into a universal phase diagram showing that viruses with high mechanical resistance cannot be self-assembled directly as spherical structures. The results of our study justify the need of a maturation step and suggest promising routes to hinder viral infections by inducing mis-assembly.
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MENDOZA, Carlos i., REGUERA, D. (david). Shape selection and mis-assembly in viral capsid formation by elastic frustration. _eLife_. 2020. Vol. 9, núm. e52525. [consulta: 20 de gener de 2026]. ISSN: 2050-084X. [Disponible a: https://hdl.handle.net/2445/179976]