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2019-03-04

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cc-by (c) García-Otero, Laura et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/148934

Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment

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https://doi.org/10.1371/journal.pone.0213279
 http://hdl.handle.net/2445/128304

Resum

BACKGROUND: Mitochondrial toxicity related to maternal combined antiretroviral treatment (cART) may have an impact on the heart of HIV-exposed uninfected (HEU) fetuses. Our objective was to evaluate fetal cardiovascular and mitochondrial biomarkers in HIV pregnancies. METHODS: Prospective cohort including 47 HIV-infected and 47 non HIV-infected pregnancies. Fetal echocardiography was performed at 26-32 weeks of pregnancy. Umbilical cord blood and placental tissue were collected to study mitochondrial DNA content (mtDNA) (ratio 12SrRNA/RNAseP) and mitochondrial function (cytochrome c oxidase, COX, enzymatic activity) normalized by mitochondrial content (citrate synthase, CS). RESULTS: HEU fetuses showed hypertrophic hearts (left myocardial wall thickness: HIV mean 3.21 mm (SD 0.81) vs. non-HIV 2.72 (0.42), p = 0.012), with signs of systolic and diastolic dysfunction (isovolumic relaxation time: HIV 52.2 ms (8.85) vs. non-HIV 42.5 ms (7.30); p<0.001). Cord blood mitochondrial content was significantly increased in HIV-exposed fetuses (CS activity: HIV 82.9 nmol/min.mg of protein (SD 40.5) vs. non-HIV 56.7 nmol/min.mg of protein (28.4); p = 0.007), with no differences in mtDNA content and COX activity. Both myocardial and mitochondrial mass parameters were significantly associated with zidovudine exposure. CONCLUSIONS: HEU fetuses showed signs of increased myocardial and mitochondrial mass associated with maternal zidovudine treatment, suggesting a fetal adaptive response to cART toxicity.

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Podeu consultar les dades crues associades a aquest article a: http://hdl.handle.net/2445/128304 [recurs relacionat]

Matèries

Fetus, Antiretrovirals, VIH (Virus)

Matèries (anglès)

Fetus, Antiretroviral agents, HIV (Viruses)

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (BCNatal Fetal Medicine Research Center)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

GARCÍA-OTERO, Laura, LÓPEZ, Marta, GUITART MAMPEL, Mariona, MORÉN NÚÑEZ, Constanza, GONCÉ MELLGREN, Anna, ESTEVE, Carol, SALAZAR, Laura, GÓMEZ, Olga, MARTÍNEZ CRESPO, Josep m. (josep maria), TORRES MURILLO, Berta, CÉSAR DIAZ, Sergio, GARRABOU TORNOS, Glòria, CRISPI BRILLAS, Fàtima, GRATACÓS SOLSONA, Eduard. Cardiac and mitochondrial function in HIV-uninfected fetuses exposed to antiretroviral treatment. _PLoS One_. 2019. Vol. 14, núm. 3, pàgs. e0213279. [consulta: 24 de gener de 2026]. ISSN: 1932-6203. [Disponible a: https://hdl.handle.net/2445/148934]

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