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2016-08

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/160461

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

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https://doi.org/10.1038/ng.3598

Resum

Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we performed the largest genetic study of migraine to date, comprising 59,674 cases and 316,078 controls from 22 GWA studies. We identified 44 independent single nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that map to 38 distinct genomic loci, including 28 loci not previously reported and the first locus identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.

Matèries

Gens, Migranya

Matèries (anglès)

Genes, Migraine

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Citació

International Headache Genetics Consortium, CORMAND RIFÀ, Bru and SINTAS VIVES, Cèlia. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics. 2016. Vol. 48, num. 8, pags. 856-866. ISSN 1061-4036. [consulted: 17 of August of 2026]. Available at: https://hdl.handle.net/2445/160461

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