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2021-08-12

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cc-by (c) Brotons, Pedro et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/183875

The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.

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https://doi.org/10.3390/v13081598

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We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission.

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SARS-CoV-2, Enterovirus, Llar

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SARS-CoV-2, Enteroviruses, Éssers humans

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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BROTONS, Pedro, JORDÁN GARCÍA, Iolanda, BASSAT ORELLANA, Quique, HENARES, Desiree, FERNÁNDEZ DE SEVILLA ESTRACH, Mariona, AJANOVIC, Sara, REDIN, A., FUMADÓ, Victoria, BARO, Bàrbara, CLAVEROL, Joana, VARO, Rosauro, CUADRAS, Daniel, HECHT, Jochen, BARRABEIG I FABREGAT, Irene, GARCÍA GARCÍA, Juan josé, LAUNES MONTAÑA, Cristian, MUÑOZ-ALMAGRO, Carmen. The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study.. _Viruses_. 2021. Vol. 13, núm. 8, pàgs. 1598. [consulta: 23 de gener de 2026]. ISSN: 1999-4915. [Disponible a: https://hdl.handle.net/2445/183875]

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