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2025

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cc-by (c) Ayats-Vidal, R. et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/231051

Erythrocyte Fatty Acid Profile, Mediterranean Diet and Asthma Severity in Childhood Allergic Asthma: Preliminary Findings from a Cohort Study in Spain

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Recurs relacionat

https://doi.org/10.3390/nu17071161

Resum

Allergic asthma incidence is increasing, probably due to the influenceof the Western diet. Adherence to the Mediterranean diet (MedDi) and omega-3 fattyacids composition (n-3 PUFAs) may be linked to a lower prevalence and lower severity ofchildhood asthma; however, the association is inconclusive. This study aims to examinethe relationship between adherence to the MedDi, asthma severity, and erythrocyte fattyacid profile in Spanish children with atopic asthma. Methods: This study was based on anongoing single-center, prospective, cross-sectional cohort study involving 95 consecutivelyenrolled children from an outpatient tertiary referral center. Of these, 55 had atopic asthmaand 40 were age-matched healthy controls. Blood samples were collected to analyze theerythrocyte fatty acid content. Participants’ demographic and clinical characteristics wererecorded using validated self-reported outcome measures. Asthma severity and pulmonaryfunction were assessed. Results: Asthmatics presented poorer adherence to the MedDi(p = 0.034) and lower n-3 PUFA levels (p = 0.019). Asthmatics with poor adherence to theMedDi were more likely to be overweight (p = 0.001) and to have moderate-severe asthma(p = 0.049); and lower n-3 PUFAs levels (p = 0.033). Children with mild asthma had highern-3 PUFAs levels than those with moderate or severe asthma (p = 0.036). Conclusions:These findings highlight that adherence to the MedDi and a high erythrocyte fatty acidprofile seem to have a protective effect in childhood asthma. Future well-controlled interventionsshould focus on the effects of MedDi patterns and n-3 PUFA intake on the primaryprevention of childhood asthma.

Matèries

Àcids grassos, Asma infantil, Malalties de l'aparell respiratori en els infants

Matèries (anglès)

Fatty acids, Asthma in children, Respiratory diseases in children

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Col·leccions

Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

CASTRO-MARRERO, Jesús, et al. Erythrocyte Fatty Acid Profile, Mediterranean Diet and Asthma Severity in Childhood Allergic Asthma: Preliminary Findings from a Cohort Study in Spain. Nutrients. 2025. Vol. 17, num. 7, pags. 1161. ISSN 2072-6643. [consulted: 3 of August of 2026]. Available at: https://hdl.handle.net/2445/231051

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