Document type
ArticleVersion
Published versionPublication date
Publication license
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/193115
Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
The incidence of obesity and its related disorders has increased dramatically in recent years and has become a pandemic. Adipose tissue is a crucial regulator of these diseases due to its endocrine capacity. Thus, understanding adipose tissue metabolism is essential to finding new effective therapeutic approaches. The 'omic' revolution has identified new concepts about the complexity of the signaling pathways involved in the pathophysiology of adipose tissue-associated disorders. Specifically, advances in transcriptomics have allowed its application in clinical practice and primary or secondary prevention. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of adipose tissue since they can modulate gene expression at the epigenetic, transcriptional, and post-transcriptional levels. They interact with DNA, RNA, protein complexes, other non-coding RNAs, and microRNAs to regulate a wide range of physiological and pathological processes. Here, we review the emerging field of lncRNAs, including how they regulate adipose tissue biology, and discuss circulating lncRNAs, which may represent a turning point in the diagnosis and treatment of adipose tissue-associated disorders. We also highlight potential biomarkers of obesity and diabetes that could be considered as therapeutic targets. Keywords: Adipose tissue; Biomarkers; Diabetes; Obesity; Therapeutics; lncRNA.
Subject
Subject (English)
Citation
Citation
CORRAL PLAZA, Ana, et al. Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies. Biochemical Pharmacology. 2022. Vol. 206, num. 115305. ISSN 0006-2952. [consulted: 12 of June of 2026]. Available at: https://hdl.handle.net/2445/193115