Comparison of clinical outcomes between Maastricht-III kidney donors >65 years old and donors after brain death: a single center, matched-pair study

Abstract

Introduction & Objectives: the inclusion of Maastricht Category-III (MIII) donors after circulatory death (DCD) has increased the donors' pool and, therefore, kidney transplants (KT). However, DCD have higher incidence of delayed graft function (DGF) compared to donors after brain death (DBD), being age one of its risk factors. Available data of using expanded criteria DCD is still controversial and conflicting in the current medical practice. The purpose of this study was to compare aged DCD outcomes to DBD regarding DGF, graft and patient's survival. Materials & Methods: We performed a retrospective observational matched-pair analysis of DCD >65 years old (yo) compared to DBD with minimum 1 year follow-up. Patients were matched according to donors' age (±2 years), receptors' age (±5 years), cold ischemia time (CIT) (±3 hours) and type of storage (cold vs perfusion machine). Stata14 program was used for statistical analysis: Tstudent, χ2 for descriptive analysis, logistic regression for DGF and Kaplan Meier survival curves.