Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/221180
Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226 and smoking associated with overall survival of early-stage NSCLC
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The interaction between DNA methylation of tripartite motif containing 27 (cg05293407TRIM27 ) and smoking has previously been identified to reveal histologically heterogeneous effects of TRIM27 DNA methylation on early-stage non-small cell lung cancer (NSCLC) survival. However, to understand the complex mechanisms underlying NSCLC progression, we searched three-way interactions. A two-phase study was adopted to identify three-way interactions in the form of pack-year of smoking (number of cigarettes smoked per day × number of years smoked) × cg05293407TRIM27 × epigenome-wide DNA methylation CpG probe. Two CpG probes were identified with FDR-q≤0.05 in the discovery phase and P≤0.05 in the validation phase: cg00060500KIAA0226 and cg17479956EXT2 . Compared to a prediction model with only clinical information, the model added 42 significant three-way interactions using a looser criterion (discovery: FDR-q≤0.10, validation: P≤0.05), had substantially improved the area under the receiver operating characteristic curve (AUC) of the prognostic prediction model for both 3-year and 5-year survival. Our research identified the complex interaction effects among multiple environment and epigenetic factors, and provided therapeutic target for NSCLC patients.
Matèries
Matèries (anglès)
Citació
Citació
JI, Xinyu, LIN, Lijuan, FAN, Juanjuan, LI, Yi, WEI, Yongyue, SHEN, Sipeng, SU, Li, SHAFER, Andrea, BJAANAES, Maria moksnes, KARLSSON, Anna, PLANCK, Maria, STAAF, Johan, HELLAND, Åslaug, ESTELLER, Manel, ZHANG, Ruyang, CHEN, Feng, CHRISTIANI, David c.. Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226 and smoking associated with overall survival of early-stage NSCLC. _Molecular Oncology_. 2021. Vol. 16, núm. 3, pàgs. 717-731. [consulta: 25 de gener de 2026]. ISSN: 1574-7891. [Disponible a: https://hdl.handle.net/2445/221180]