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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/195145
The Solid State Landscape of the Sildenafil Drug
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Sildenafil, the active ingredient of the drug developed by Pfizer for the treatment of erectile dysfunction was firstly synthesized in 1989 in the United Kingdom and since then it has become one of the most prescribed drugs for sexual performance in the western world with more than 2.7 million prescriptions in the US in 2021. Since its discovery, this drug compound has attracted the interest of formulators and crystallographers, with a high number of crystal forms of sildenafil being found and characterized, including polymorphs, hydrates, solvates, salts and cocrystals, converting it in one of the most promiscuous multicomponent crystal former drugs in the pharmaceutical sciences arena. In this minireview, the polymorph, pseudopolymorph and multicomponent solid forms landscape of sildenafil is presented through a comprehensive compilation of their 42 solid forms reported in literature
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BARBAS CAÑERO, Rafael, LLINÀS, Antonio and PROHENS LÓPEZ, Rafael. The Solid State Landscape of the Sildenafil Drug. Journal of Pharmaceutical Sciences. 2022. Vol. 111, num. 4, pags. 1104-1109. ISSN 0022-3549. [consulted: 8 of June of 2026]. Available at: https://hdl.handle.net/2445/195145