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2019-05-15

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/158153

Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth

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https://doi.org/10.1038/s41390-019-0428-2

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Background: Although prenatal and postnatal programming of metabolic diseases in adulthood is well established, the mechanims underpinning metabolic programming are not. DLK1, a key regulator of fetal development, inhibits adipocyte differentiation and restricts fetal growth. Methods: Assess Dlk1 expression in Wistar rat model of catch-up growth following intrauterine restriction. Dams fed ad libitum deliverd control pups (C) and dams on a 50% calorie-restricted diet delivered pups with low birth weight (R). Restricted offspring fed a standard rat chow showd catch-up growth (R/C) but those kept on a calorie-restricted diet did not (R/R). Results: Decreased Dlk1 expression was observed in adipose tissue and skeletal muscle of R/C pups along with excessive visceral fat accumulation, decreased circulating adiponectin, increased triglycerides and HOMA-IR (from p<0.05 to p<0.001). Moreover, in R/C pups, the reduced Dlk1 expression in adipose tissue and skeletal muscle correlated with visceral fat (r= -0.820; p<0.0001) and HOMA-IR (r= -0.745; p=0.002). Conclusions: Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction. Modulation of Dlk1 expression could be among the targets of the early prevention of fetal preogramming of adult metabolic disorders.

Matèries

Medicina prenatal, Trastorns del metabolisme, Rates (Animals de laboratori)

Matèries (anglès)

Prenatal medicine, Disorders of metabolism, Rats as laboratory animals

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

Citació

CARRERAS BADOSA, Gemma, REMESAR BETLLOCH, Xavier, PRATS PUIG, Anna, XARGAY I TORRENT, Sílvia, LIZARRAGA MOLLINEDO, Esther, ZEGHER, Francis de, IBÁÑEZ, Lourdes, BASSOLS, Judit, LÓPEZ BERMEJO, Abel. Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth. _Pediatric Research_. 2019. Vol. 86, núm. 195-201. [consulta: 21 de gener de 2026]. ISSN: 0031-3998. [Disponible a: https://hdl.handle.net/2445/158153]

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