Carregant...
Tipus de document
AltresData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223764
Computational models for describing Ras nanocluster dynamics and PRMT5-mediated modulation
Títol de la revista
Autors
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
The computational models implemented and exploited for the different analysis performed in the
thesis "Spatiotemporal regulation of Ras-driven MAPK signaling: a stochastic and computational
approach to Ras nanocluster dynamics and PRMT5-mediated modulation" were defined and
simulated using a stochastic approach similar to Gillespie’s Stochastic Simulation Algorithm (SSA),
in which the biochemical reactions of the signaling cascade are treated as a set of discrete stochastic
events [1-3]. Each event is modeled as a Poissonian process with its occurrence frequency
characterized by the corresponding reaction rate. All simulations were implemented in the Fortran
programming language, specifically using the GNU Fortran 77 compiler.
Two different basic configurations of the EGF-Ras-ERK MAPK signaling pathway have been
modelled and simulated: i) a configuration based on the classical three-tiered cascade architecture
comprising the core signaling module Raf-MEK-ERK, and ii) a configuration that localizes all
pathway components and signaling events within discrete, membrane-associated nanoclusters.
The different models are listed below
Matèries
Matèries (anglès)
Citació
Col·leccions
Citació
JURADO SÁENZ, Manuel. Computational models for describing Ras nanocluster dynamics and PRMT5-mediated modulation. [consulta: 6 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/223764]