Lipid metabolism in metastasis and therapy

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dc.contributor.authorMartín Pérez, Miguel
dc.contributor.authorUrdiroz Urricelqui, Uxue
dc.contributor.authorBigas, Claudia
dc.contributor.authorAznar Benitah, Salvador
dc.date.accessioned2022-02-09T16:46:12Z
dc.date.available2022-11-20T06:10:29Z
dc.date.issued2021-11-20
dc.date.updated2022-02-09T10:13:57Z
dc.description.abstractAlterations in lipid metabolism are being increasingly implicated in the initiation, aggressiveness, and progression to metastasis of cancers. Recent advances have shown that high levels of fat availability and altered lipid metabolism can promote the metastatic process by i) providing energy for cancer cells, thereby supporting invasion and colonization, ii) promoting their survival by enhancing antioxidative, antiapoptotic mechanisms, and therapy resistance, and iii) inhibiting the immune surveillance from detecting/removing tumor cells. These findings are especially disturbing given the alarmingly high fat intake within our modern diet. However, the reprogramming of fat metabolism exhibited by cancer cells and intratumor immune cells promises to generate new pharmacological opportunities to treat metastasis. © 2021 Elsevier Ltdca
dc.format.extent20 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idimarina6543012
dc.identifier.issn2452-3100
dc.identifier.urihttps://hdl.handle.net/2445/183023
dc.language.isoengca
dc.publisherElsevierca
dc.relation.isformatofversió postprint del document publicat a: https://doi.org/10.1016/j.coisb.2021.100401
dc.relation.ispartofCurrent Opinion In Systems Biology, 2021, vol.28, num.100401
dc.relation.urihttps://doi.org/10.1016/j.coisb.2021.100401
dc.rightscc by-nc-nd (c) Elsevier, 2021
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
dc.subject.classificationMetabolisme dels lípids
dc.subject.classificationMetàstasi
dc.subject.classificationTractament adjuvant del càncer
dc.subject.otherLipid metabolism
dc.subject.otherMetastasis
dc.subject.otherAdjuvant treatment of cancer
dc.titleLipid metabolism in metastasis and therapyca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/acceptedVersion

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Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))