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2021-11-24

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cc-by (c) Casas Recasens, Sandra et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/194795

Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD

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https://doi.org/10.3389/fmed.2021.761767

Abstract

Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that the COPD can have roots early in life. Here we hypothesise that the accelerated ageing markers might have a role in the pathobiology of young COPD. The objective of this study was to compare two hallmarks of ageing, telomere length (TL), and mitochondrial DNA copy number (mtDNA-CN, as a surrogate marker of mitochondrial dysfunction) in young (≤50 years) and old (>50 years) smokers, with and without COPD. Both, TL and mtDNACN were measured in whole blood DNA by quantitative PCR [qPCR] in: (1) young ever smokers with (n = 81) or without (n = 166) COPD; and (2) old ever smokers with (n = 159) or without (n = 29) COPD. A multivariable linear regression was used to assess the association of TL and mtDNA-CN with lung function. We observed that in the entire study population, TL and mtDNA-CN decreased with age, and the former but not the latter related to FEV1/FVC (%), FEV1 (% ref.), and DLCO (% ref.). The short telomeres were found both in the young and old patients with severe COPD (FEV1 < 50% ref.). In addition, we found that TL and mtDNA-CN were significantly correlated, but their relationship was positive in younger while negative in the older patients with COPD, suggesting a mitochondrial dysfunction. We conclude that TL, but not mtDNA-CN, is associated with the lung function impairment. Both young and old patients with severe COPD have evidence of accelerated ageing (shorter TL) but differ in the direction of the correlation between TL and mtDNA-CN in relation to age.

Subject

Bronquitis, Malalties pulmonars obstructives cròniques, ADN mitocondrial, Telòmer, ADN mitocondrial

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Bronchitis, Chronic obstructive pulmonary diseases, Mitochondrial DNA, Telomere, Mitochondrial DNA

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (ISGlobal)

Citation

CASAS RECASENS, Sandra, et al. Telomere Length but Not Mitochondrial DNA Copy Number Is Altered in Both Young and Old COPD. Frontiers in Medicine. 2021. Vol. 8, num. 761767, pags. 1-11. ISSN 2296-858X. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/194795

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