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Raw sewage harbors diverse viral populations
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At this time, about 3,000 different viruses are recognized, but metagenomic studies suggest that these viruses are a small fraction of the viruses that exist in nature. We have explored viral diversity by deep sequencing nucleic acids obtained from virion populations enriched from raw sewage. We identified 234 known viruses, including 17 that infect humans. Plant, insect, and algal viruses as well as bacteriophages were also present. These viruses represented 26 taxonomic families and included viruses with single-stranded DNA (ssDNA), double-stranded DNA (dsDNA), positive-sense ssRNA [ssRNA(¿)], and dsRNA genomes. Novel viruses that could be placed in specific taxa represented 51 different families, making untreated wastewater the most diverse viral metagenome (genetic material recovered directly from environmental samples) examined thus far. However, the vast majority of sequence reads bore little or no sequence relation to known viruses and thus could not be placed into specific taxa. These results show that the vast majority of the viruses on Earth have not yet been characterized. Untreated wastewater provides a rich matrix for identifying novel viruses and for studying virus diversity.
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CANTALUPO, Paul g., CALGUA DE LEÓN, Byron thomas, ZHAO, Guoyan, HUNDESA GONFA, Ayalkibet, WIER, Adam d., KATZ, Josh p., GRABE, Michael, HENDRIX, Roger w., GIRONÈS LLOP, Rosina, WANG, David, PIPAS, James m.. Raw sewage harbors diverse viral populations. _mBio_. 2011. Vol. 2(5):e00180-11. [consulta: 25 de febrer de 2026]. ISSN: 2150-7511. [Disponible a: https://hdl.handle.net/2445/23303]