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journal.ppat.1010631.pdf (3.98 MB)

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2022-07-11

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cc by (c) Ginex, Tiziana et al., 2022
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/189320

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

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https://doi.org/10.1371/journal.ppat.1010631

Abstract

The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness.

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SARS-CoV-2, Mutació (Biologia)

Subject (English)

SARS-CoV-2, Mutation (Biology)

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Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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GINEX, Tiziana, et al. The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation. Plos Pathogens. 2022. Vol. 18, num. 7. ISSN 1553-7374. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/189320

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