Carregant...
Miniatura

Tipus de document

Treball de fi de grau

Data de publicació

Llicència de publicació

cc-by-nc-nd (c) Colomer, 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171220

Mechanosensitive single molecule dynamics of myosin II

Títol de la revista

ISSN de la revista

Títol del volum

Recurs relacionat

Resum

In this project we have characterised the dynamics of single myosin II molecules in stem cells under mechanical stress combining high spatial and time resolution microscopy with image analysis and simulations. We show that in the bleb, intensity of myosin spots increases as they assemble into bipolar thick filaments. In comparison with the myosin II under the nucleus, in the bleb they undergo a super dffusive motion which could drive the bleb contraction. We have analysed their spatial distribution using DBSCAN clustering analysis and we have performed Cytosim simulations to study the myosin II dynamics in the retraction bleb. This analysis sets the framework and the computational pipeline for further experiments.

Descripció

Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2020, Tutors: Valeria Venturini , Stefan Wieser i Jaume Casademunt

Citació

Citació

COLOMER ROSELL, Mariona. Mechanosensitive single molecule dynamics of myosin II. [consulta: 28 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/171220]

Exportar metadades

JSON - METS

Compartir registre