Circadian Regulation of Adult Stem Cell Homeostasis and Aging

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dc.contributor.authorAznar Benitah, Salvador
dc.contributor.authorWelz, Patrick Simon
dc.date.accessioned2021-06-01T16:21:36Z
dc.date.issued2020-06-04
dc.date.updated2021-06-01T10:53:35Z
dc.description.abstractThe circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue level, the circadian clock ensures coherent temporal organismal physiology. Recent advances in our understanding of adult stem cell physiology suggest that aging and perturbations in circadian rhythmicity in stem cells are tightly intertwined. Here we discuss how circadian rhythms regulate and synchronize adult stem cell functions and how alterations in clock function during aging modulate the extrinsic and intrinsic mechanisms that determine adult stem cell homeostasis.ca
dc.format.extent14
dc.format.mimetypeapplication/pdf
dc.identifier.idimarina6279288
dc.identifier.issn1934-5909
dc.identifier.urihttps://hdl.handle.net/2445/177900
dc.language.isoengca
dc.publisherElsevierca
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.stem.2020.05.002
dc.relation.ispartofCell Stem Cell, 2020, Vol.26, num. 6, p. 817-831
dc.relation.urihttps://doi.org/10.1016/j.stem.2020.05.002
dc.rightscc by-nc-nd (c) Elsevier, 2020
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
dc.subject.classificationCèl·lules mare
dc.subject.classificationEnvelliment
dc.subject.classificationRitmes circadiaris
dc.subject.otherStem cells
dc.subject.otherAging
dc.subject.otherCircadian rhythms
dc.titleCircadian Regulation of Adult Stem Cell Homeostasis and Agingca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/acceptedVersion

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