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IntJMolSciences_Castane_2025.pdf (3.6 MB)

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Data de publicació

2025-09-02

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cc-by (c) Castañé Vilafranca, Helena et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223588

Dysregulation of the FGF21-adiponectin axis in a large cohort of patients with severe obesity and liver disease

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Recurs relacionat

https://doi.org/10.3390/ijms26178510

Resum

We investigated the impact of liver damage on systemic inter-organ communication in an extensive observational case-control study of 923 patients with severe obesity and biopsy-confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH) undergoing bariatric surgery. Using a comprehensive panel of circulating organokines, including fibroblast growth factor (FGF) 19, FGF21, adiponectin, galectin-3, irisin, and leptin, along with choline metabolites, we characterized metabolic signaling patterns associated with liver disease severity. Compared to controls, patients with MASLD/MASH exhibited significantly lower levels of FGF19, choline, and trimethylamine, while FGF21, galectin-3, irisin, and leptin were elevated. Sex-specific alterations in leptin and adiponectin were observed in patients with severe obesity but not in controls. Network analysis revealed a complex and individualized interplay among organokines, shaped by age, sex, and anthropometric factors. Despite this complexity, a dysregulation of the FGF21-adiponectin axis was associated with more advanced liver involvement. The large cohort and comprehensive organokine profiling studied provide valuable insights into the role of the FGF21-adiponectin axis on systemic metabolic alterations in severe obesity and their potential clinical implications.

Matèries

Malalties del fetge, Trastorns del metabolisme

Matèries (anglès)

Liver diseases, Disorders of metabolism

Citació

Col·leccions

Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citació

CASTAÑÉ VILAFRANCA, Helena, et al. Dysregulation of the FGF21-adiponectin axis in a large cohort of patients with severe obesity and liver disease. International Journal of Molecular Sciences. 2025. Vol. 26, num. 17, pags. 8510. ISSN 1422-0067. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/223588

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