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IntJMolSciences_Castane_2025.pdf (3.6 MB)

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2025-09-02

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cc-by (c) Castañé Vilafranca, Helena et al., 2025
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/223588

Dysregulation of the FGF21-adiponectin axis in a large cohort of patients with severe obesity and liver disease

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Related resource

https://doi.org/10.3390/ijms26178510

Abstract

We investigated the impact of liver damage on systemic inter-organ communication in an extensive observational case-control study of 923 patients with severe obesity and biopsy-confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH) undergoing bariatric surgery. Using a comprehensive panel of circulating organokines, including fibroblast growth factor (FGF) 19, FGF21, adiponectin, galectin-3, irisin, and leptin, along with choline metabolites, we characterized metabolic signaling patterns associated with liver disease severity. Compared to controls, patients with MASLD/MASH exhibited significantly lower levels of FGF19, choline, and trimethylamine, while FGF21, galectin-3, irisin, and leptin were elevated. Sex-specific alterations in leptin and adiponectin were observed in patients with severe obesity but not in controls. Network analysis revealed a complex and individualized interplay among organokines, shaped by age, sex, and anthropometric factors. Despite this complexity, a dysregulation of the FGF21-adiponectin axis was associated with more advanced liver involvement. The large cohort and comprehensive organokine profiling studied provide valuable insights into the role of the FGF21-adiponectin axis on systemic metabolic alterations in severe obesity and their potential clinical implications.

Subject

Malalties del fetge, Trastorns del metabolisme

Subject (English)

Liver diseases, Disorders of metabolism

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citation

CASTAÑÉ VILAFRANCA, Helena, et al. Dysregulation of the FGF21-adiponectin axis in a large cohort of patients with severe obesity and liver disease. International Journal of Molecular Sciences. 2025. Vol. 26, num. 17, pags. 8510. ISSN 1422-0067. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/223588

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