Carregant...
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/223588
Dysregulation of the FGF21-adiponectin axis in a large cohort of patients with severe obesity and liver disease
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
We investigated the impact of liver damage on systemic inter-organ communication in an extensive observational case-control study of 923 patients with severe obesity and biopsy-confirmed metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH) undergoing bariatric surgery. Using a comprehensive panel of circulating organokines, including fibroblast growth factor (FGF) 19, FGF21, adiponectin, galectin-3, irisin, and leptin, along with choline metabolites, we characterized metabolic signaling patterns associated with liver disease severity. Compared to controls, patients with MASLD/MASH exhibited significantly lower levels of FGF19, choline, and trimethylamine, while FGF21, galectin-3, irisin, and leptin were elevated. Sex-specific alterations in leptin and adiponectin were observed in patients with severe obesity but not in controls. Network analysis revealed a complex and individualized interplay among organokines, shaped by age, sex, and anthropometric factors. Despite this complexity, a dysregulation of the FGF21-adiponectin axis was associated with more advanced liver involvement. The large cohort and comprehensive organokine profiling studied provide valuable insights into the role of the FGF21-adiponectin axis on systemic metabolic alterations in severe obesity and their potential clinical implications.
Matèries (anglès)
Citació
Citació
CASTAÑÉ VILAFRANCA, Helena, JIMÉNEZ FRANCO, Andrea, ONOIU, Alina iuliana, CAMBRA CORTÉS, Vicente, HERNÁNDEZ AGUILERA, Anna, PARADA DOMÍNGUES, David, RIU, Francisco, ZORZANO OLARTE, Antonio, CAMPS, Jordi, JOVEN, Jorge. Dysregulation of the FGF21-adiponectin axis in a large cohort of patients with severe obesity and liver disease. _International Journal of Molecular Sciences_. 2025. Vol. 26, núm. 17, pàgs. 8510. [consulta: 3 de gener de 2026]. ISSN: 1422-0067. [Disponible a: https://hdl.handle.net/2445/223588]